Example Platforms / Applications

While employed at GE Healthcare Biosciences, Amersham Biosciences and Imaging Research, VisiMatik principals held leadership positions, both technical and organizational, in the development of major commercial platforms and applications for life sciences, drug discovery, genomics and proteomics research. These platforms and applications are in use in thousands of locations across the world, from University labs to small and large Biotech and Pharma.

Domain

Platform

Applications

Histopathology


H&E stained tissue

Visualization and analysis of digital histopathology slide images

  • Chromogenic (H+E, Dab), fluorescent immunostaining
  • Full face slides / Tissue microarrays (TMA)

High Content Analysis
(HCA, Cell Based Assay)


Cell based assay - green GFP

IN Cell Analyzer 1000* (2001-)
IN Cell Investigator* (2003-)

One of the market leading HCA systems

  • Advanced instrument control (modalities, automation, performance, image bandwidth)
  • Comprehensive setup, self-diagnostics, service, logging functionality
  • Fully automated, robust image analysis assays (e.g. intra-cellular transport, apoptosis and cell viability, cell motility analysis, cell cycle, ...)
  • Biologist-programmable image analysis framework

High-Throughput Screening
(HTS)


wellplate with colorimetric assay

LeadSeeker* (1998-)
AssayVision* (1998-)

One of the first HTS systems

  • Advanced modalities: Luminescence, Fluorescent, Time Resolved Fluorescence (TRF), Fluorescence Polarization (FP), Fluorescence Resonance Energy Transfer (FRET), Time Resolved FRET (TR-FRET)
  • Advanced image corrections (ultra cooled camera, up to 30 minute exposures)
  • Grid alignment, cross-talk correction, semi-automated setup/focusing

Genomics, Proteomics


Scientist looking at microarray slide

ArrayVision* (1998-)
ArrayStat* (2001-2005)
OEM Imager (2002-2005)

DNA and protein microarrays (one of the first commercial systems)

  • High Dynamic Range (HDR) image acquisition
  • Array/block/spot finding+alignment
  • Labeling / Replicates
  • Sophisticated quantification
  • Normalization (background, reference, dye effects)
  • Calibration (e.g. protein concentration)
  • Hypothesis testing w/ pooled error model

General Life Sciences


Darkfield microscopy image

MCID* (1991-)

Long-standing mainstay for basic research community

  • Quantitative Auto-Radiography,
  • 1D/2D Gels,
  • Receptor Binding, InSitu Hybridization,
  • Microscopy, Multi-Color Fluorescence, Time-Series Acquisition,
  • Tile Field Montaging, Deconvolution
  • 3D rendering,
  • Stereology, ...

Genome Wide Association Studies
(GWAS)


Genome correlation illustration

Sophisticated statistical algorithms and data processing of very large datasets (10 – 50 GB)


* These product platforms as well as related trademarks and copyrights belong to GE Healthcare Life Sciences, all rights reserved.